WebApr 4, 2024 · In this way, differential miRNA expression leads to cancer stem cell heterogeneity within colorectal tumor tissue. “It’s an early research finding and needs to be followed up with other experiments, but it has clear relevance to the clinic,” Boman said. WebJul 4, 2024 · The cancer stem cell (CSC) theory suggests that CSCs with dysregulated self-renewal and asymmetric cell division serve as a source of intra-tumoral heterogeneity. This heterogeneity complicates the diagnosis and treatment of cancer patients, because CSCs can give rise to aggressive clones that are metastatic and insensitive to multiple …
Toward understanding cancer stem cell heterogeneity in …
WebFeb 16, 2024 · The second model that is proposed to install intra-tumor heterogeneity is the cancer stem cell (CSC) model. This model suggests that only a subset of cancer cells possess indefinite self-renewal ability to initiate and maintain tumor growth. Therefore, tumors are organized in a hierarchical fashion, equivalent to the normal tissue hierarchy ... WebNov 23, 2024 · The translational interest in the intratumoral heterogeneity of hepatocellular carcinoma (HCC) has been increasing. The dismal prognosis of this pathology is linked to the features of the HCC harbouring cancer stem cells (CSC), represented by EpCAM-expression. However, the extent of the impact of intratumoral distribution of CSC … inappbrowser documentation
Frontiers Cancer Stem Cells—Origins and …
WebApr 13, 2024 · The origin of CAFs can be quite heterogeneous, and the main sources of CAFs in TME are NFs. Growth factors like TGF-1 and stromal SDF-1 can be secreted by tumor cells to enable the conversion of ... WebJ.W. Cassidy, A. Bruna, in Patient Derived Tumor Xenograft Models, 2024 Evolution of the Cancer Stem Cell Model. In summary, tumor heterogeneity is undoubtedly due, at least in part, to the stability of multiple genomic clonal populations within a neoplasm. 18 These arise from divergent evolution of the originating cells’ progeny and may be sustained by … WebApr 17, 2024 · We report that when considering 21 solid cancer types, immune cell exclusion is widely associated with the presence of a stem cell-like phenotype in tumors (“stemness”). Stemness positively correlates with higher intratumoral heterogeneity, possibly by protecting antigenic clones from elimination by the immune system. inapp purchase on macbook