Durocher cip2a

WebDurocher D, et al. The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Nature Cancer. 2: 1357-1371. PMID 35121901 DOI: ... Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB. The molecular basis of FHA domain:phosphopeptide binding … WebThe CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis Mara De Marco Zompit, Clémence Mooser, Salomé Adam, Silvia Emma Rossi, Alain Jeanrenaud, Pia-Amata Leimbacher, Daniel Fink, …

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WebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn … WebMar 26, 2024 · This study is the first to describe a pathogenic CIP2A mutation in humans, which might disrupt neuronal development via enhancing mTOR and c-Myc protein expressions, shedding light in mechanisms of Dandy-Walker variant pathogenesis. biomarker for metastasis and prognosis in clear cell renal cell carcinoma WebFeb 9, 2024 · VDOMDHTMLtml> Daniel Durocher on Twitter: "CIP2A encodes a fascinating protein linked to all kinds of processed but not DNA repair or genome stability so the challenge was to understand why CIP2A was essential for the viability of BRCA1/2-deficient cells." We've detected that JavaScript is disabled in your browser. smart card bus pass brighton

CIP2A is a prime synthetic-lethal target for BRCA-mutated …

Category:The CIP2A–TOPBP1 axis safeguards chromosome stability …

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Durocher cip2a

57650 - Gene ResultCIP2A cellular inhibitor of PP2A [ (human)]

WebThe CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Durocher and colleagues identify CIP2A through synthetic … WebApr 27, 2024 · Protein phosphatase 2A (PP2A) is a phosphatase and a tumor suppressor, which is often inhibited in malignant cells by the inhibitory proteins cancerous inhibitor of PP2A (CIP2A), SET, and binding protein for SET (SETBP1), leading to abnormal proliferation and differentiation. 1 High levels of CIP2A correlate with suppressed PP2A …

Durocher cip2a

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WebDec 1, 2024 · CIP2A, a 90 kDa oncoprotein, was originally named KIAA1524 or p90 which is encoded by KIAA1524 gene located on 3q13.13 in human [11].Sequence analysis of KIAA1524 demonstrates insignificant homology to any protein with known function, but the protein has several protein–protein interaction domains [12].Moreover, the studies … Webformation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer. Thus, our data show that CIP2A is a human oncopro-tein that inhibits PP2A and …

WebbioRxiv.org - the preprint server for Biology WebAug 12, 2009 · Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified human oncoprotein that inhibits c-Myc protein degradation in cancer cells. CIP2A has been found to be overexpressed in different human cancers, but its clinical relevance has not yet been established.

WebFeb 7, 2024 · that CIP2A binds to PP2A B56a and B56c tumor suppressor subunits directly. Both the CIP2A N-terminal region and CIP2A dimerization contribute to maximal B56 binding. We further show that B56 bind-ing determines CIP2A protein stability in human cell lines. Together, these results provide important insights into poorly understood

WebFeb 8, 2024 · CIP2A is actively exported from the cell nucleus in interphase but, upon nuclear envelope breakdown at the onset of mitosis, gains access to chromatin where it …

WebJul 16, 2024 · CIP2A is actively exported from the cell nucleus in interphase but, upon nuclear envelope breakdown at the onset of mitosis, gains access to chromatin where it … hillary essigWebNature Cancer The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer – Nature Cancer - Durocher and colleagues identify CIP2A through synthetic lethal CRISPR screens as a key regulator of adaptive feedback mechanisms controlling chromosomal stability arising from … hillary emails congress hearingWebCIP2A is cytoplasmic in interphase but, in mitosis, accumulates at DNA lesions as part of a complex with TOPBP1, a multifunctional genome stability factor. Unlike PARP inhibition, … smart card businessWebBenefit from Durocher International’s reliable service and expertise that has expanded to logistics over the past decades. Our logistics team is dedicated to customer satisfaction, … hillary englandWebNov 11, 2024 · Durocher and colleagues identify CIP2A through synthetic lethal CRISPR screens as a key regulator of adaptive feedback mechanisms controlling chromosomal … smart card buddyWebHere, we identify CIP2A as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei... hillary epstein fleetwood mackedWebCIP2A inactivates protein phosphatase 2A (PP2A) which down-regulates Akt (Protein Kinase B) phosphorylation and stabilizes c-Myc (c-Myc oncogene product) in cancer … smart card buy